You need The Whale: :) http://www.humanscale.com/products/workspace/mousing_specifications_index.html ...or maybe not... "the subjects of Dr. Hedge's study reported that the mouse which caused the least stressful deflections -- the Whale mouse -- was also least comfortable. More than 50 percent of the users marked the Whale as "Uncomfortable or Very Uncomfortable" after using it." http://peripherals.about.com/library/weekly/aa011500a.htm ...or nix the mouse all together and use your feet... http://www.worklink.net/nohands.html The Microsoft Intellimouse Explorer is also pretty beefy, with the added bonus of being optical (or as I like to describe it, laser-guided ;). I wouldn't trade mine for the world (I have fairly big hands too.. Take note, ladies.. ;) http://www.microsoft.com/hardware/mouse/explorer.asp They make a cordless version which I (possibly mistakenly) assume would be a little larger: http://www.microsoft.com/hardware/mouse/cordless.asp